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を積極的に導入することで、脳の半球間抑制を改善して、手指の巧緻性を向上させることも大いに期待できるといえる。5で紹介した結果は、高齢化に伴う抑制機能の低下は決して不可逆的なものではなく、トレーニングによって改善できること、また、この抑制機構の改善は、脳機能の改善にもつながる可能性を示している。これまでの脳のトレーニングは脳を活性化することに重点がおかれてきたが、我々は世界ではじめて脳の抑制機構を改善することで脳機能を向上させることができることを示した。今後は、他の脳領域の機能低下した抑制を対象としたトレーニングを開発し、その有効性を検証しながら、手足協調運動機能や認知課題と運動課題の同時遂行機能などを改善できるトレーニングの提案を目指していく。謝辞本稿で紹介した研究は、多くの共同研究者のご協力の下、行った。特に5で紹介したトレーニング効果の検証は、ミズノ株式会社との共同研究として行った。ここにすべての共同研究者に感謝の意を表します。最後に日ごろから研究を支援してくれる上山恵子さん、大西映子さんに心より感謝いたします。参考文献】【1N. K. Logothetis, J. Pauls, M. Augath, T. Trinath, and A. Oeltermann, “Neurophysiological investigation of the basis of the fMRI signal,” Na-ture, vol.412, pp.150–157, 2001. DOI:10.1038/35084005.2A. Shmuel, M. Augath, A. Oeltermann, and N. K. Logothetis, “Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1,” Nature neuroscience, vol.9, no.4, pp.569–577, 2006. DOI:10.1038/nn1675.3A. T. Smith, A. L. Williams, and K. D. 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DOI: 10.1016/j.neuroim-age.2008.01.039.574-2　人の脳機能改善及びパフォーマンス向上のための研究開発：脳を適切に作動させる抑制機構の重要性