Innovation of photonic and electrochemical biosensors for cholangiocarcinoma diagnosis
Project Introduction
Cholangiocarcinoma (CCA) has high occurrence in Greater Mekong Subregion, especially in northeastern Thailand and Laos PDR, where the human liver fluke, Opisthorchis viverrine, infection is endemic. CCA patients usually present at an advanced stage and have short survival outcome after surgery because no biomarker is available.
The diagnosis of CCA is based on radiology and histopathological confirmation, which is high cost and time-consuming. Several biomarkers of CCA have been discovered in animal models and successfully verified in patients for clinical application. Biosensor platforms using photonic and electrochemical detector technology allows for a high degree of integration that facilitates from the device and sensor research laboratories into the hands of the analytical chemistry and clinical medicine communities for large-scale detection in various samples such as urine, faeces and sera. We hypothesize that using biosensing platforms to discover trace amounts of CCA biomarker in animal models could be translated into clinical application in patients. The Faculty of Medicine, KKU, Thailand (MD-KKU) signed an MOU with The National Institute of Information and Communications Technology, Japan (NICT) in 2019 and agreed to enter into a formal collaborative agreement. In order to sustain this, intends to develop different optical and electrochemical sensing technologies for CCA diagnosis. MD-KKU has existing collaborations with Department of Computer Engineering (EN-KKU), Faculty of Engineering (Chiang Mai University, CMU), Thai Microelectronics Center (TMEC) and NICT, Japan in developing optical and electrochemical sensing technologies. We also have a collaboration with Cancer Center, Lao PDR. The networking between Thailand–Laos, closely supported by NICT, will have high success for the sensing technologies to create wider impact in CCA diagnosis, not only for technical development, but also for societal impact in the Greater Mekong Subregion.
The diagnosis of CCA is based on radiology and histopathological confirmation, which is high cost and time-consuming. Several biomarkers of CCA have been discovered in animal models and successfully verified in patients for clinical application. Biosensor platforms using photonic and electrochemical detector technology allows for a high degree of integration that facilitates from the device and sensor research laboratories into the hands of the analytical chemistry and clinical medicine communities for large-scale detection in various samples such as urine, faeces and sera. We hypothesize that using biosensing platforms to discover trace amounts of CCA biomarker in animal models could be translated into clinical application in patients. The Faculty of Medicine, KKU, Thailand (MD-KKU) signed an MOU with The National Institute of Information and Communications Technology, Japan (NICT) in 2019 and agreed to enter into a formal collaborative agreement. In order to sustain this, intends to develop different optical and electrochemical sensing technologies for CCA diagnosis. MD-KKU has existing collaborations with Department of Computer Engineering (EN-KKU), Faculty of Engineering (Chiang Mai University, CMU), Thai Microelectronics Center (TMEC) and NICT, Japan in developing optical and electrochemical sensing technologies. We also have a collaboration with Cancer Center, Lao PDR. The networking between Thailand–Laos, closely supported by NICT, will have high success for the sensing technologies to create wider impact in CCA diagnosis, not only for technical development, but also for societal impact in the Greater Mekong Subregion.
Project Members
* Project Leader
| Project Members | |
|---|---|
| Full Name | Department, Institution, Country |
| Somchai Pinlaor * | Khon Kaen University, Thailand |
| Somchai Pinlaor | Khon Kaen University, Thailand |
| Chavis Srichan | Khon Kaen University, Thailand |
| Pobporn Danvirutai | Khon Kaen University, Thailand |
| Kitti Intuyod | Khon Kaen University, Thailand |
| Apisit Chaidee | Khon Kaen University, Thailand |
| Sirinapha Klungsaeng | Khon Kaen University, Thailand |
| Ukrit Mankong | Chiang Mai University, Thailand |
| Suruk Udomsom | Chiang Mai University, Thailand |
| Nithi Atthi | National Electronics and Computer Technology Center (NECTEC), Thailand |
| Pawasuth Saengdee | National Electronics and Computer Technology Center (NECTEC), Thailand |
| Rattanawan Meananeatra | National Electronics and Computer Technology Center (NECTEC), Thailand |
| Noppadon Nuntawong | National Electronics and Computer Technology Center (NECTEC), Thailand |
| Mati Horprathum | National Electronics and Computer Technology Center (NECTEC), Thailand |
| Pitak Eiamchai | National Electronics and Computer Technology Center (NECTEC), Thailand |
| Saksorn Limwichean | National Electronics and Computer Technology Center (NECTEC), Thailand |
| Sitiruk Roytrakul | National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand |
| Janthima Jaresitthikunchai | National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand |
| Narumon Phaonakrop | National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand |
| Champadeng Vongdala | Mittaphab Hospital, Lao PDR, Laos |
| Keooudone Thammavong | Mittaphab Hospital, Lao PDR, Laos |
| Toshimasa Umezawa | National Institute of Information and Communications Technology (NICT), Japan |
| Atsushi Matsumoto | National Institute of Information and Communications Technology (NICT), Japan |
| Kouichi Akahane | National Institute of Information and Communications Technology (NICT), Japan |