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Project Introduction

Cholangiocarcinoma (CCA) has high occurrence in Greater Mekong Subregion, especially in northeastern Thailand and Laos PDR, where the human liver fluke, Opisthorchis viverrine, infection is endemic. CCA patients usually present at an advanced stage and have short survival outcome after surgery because no biomarker is available.

The diagnosis of CCA is based on radiology and histopathological confirmation, which is high cost and time-consuming. Several biomarkers of CCA have been discovered in animal models and successfully verified in patients for clinical application. Biosensor platforms using photonic and electrochemical detector technology allows for a high degree of integration that facilitates from the device and sensor research laboratories into the hands of the analytical chemistry and clinical medicine communities for large-scale detection in various samples such as urine, faeces and sera. We hypothesize that using biosensing platforms to discover trace amounts of CCA biomarker in animal models could be translated into clinical application in patients. The Faculty of Medicine, KKU, Thailand (MD-KKU) signed an MOU with The National Institute of Information and Communications Technology, Japan (NICT) in 2019 and agreed to enter into a formal collaborative agreement. In order to sustain this, intends to develop different optical and electrochemical sensing technologies for CCA diagnosis. MD-KKU has existing collaborations with Department of Computer Engineering (EN-KKU), Faculty of Engineering (Chiang Mai University, CMU), Thai Microelectronics Center (TMEC) and NICT, Japan in developing optical and electrochemical sensing technologies. We also have a collaboration with Cancer Center, Lao PDR. The networking between Thailand–Laos, closely supported by NICT, will have high success for the sensing technologies to create wider impact in CCA diagnosis, not only for technical development, but also for societal impact in the Greater Mekong Subregion.

Project Members

* Project Leader
Project Members
Full Name Department, Institution, Country
Somchai Pinlaor * Khon Kaen University, Thailand
Chavis Srichan Khon Kaen University, Thailand
Pobporn Danvirutai Khon Kaen University, Thailand
Kitti Intuyod Khon Kaen University, Thailand
Apisit Chaidee Khon Kaen University, Thailand
Sirinapha Klungsaeng Khon Kaen University, Thailand
Ukrit Mankong Chiang Mai University, Thailand
Suruk Udomsom Chiang Mai University, Thailand
Nithi Atthi National Electronics and Computer Technology Center (NECTEC), Thailand
Pawasuth Saengdee National Electronics and Computer Technology Center (NECTEC), Thailand
Rattanawan Meananeatra National Electronics and Computer Technology Center (NECTEC), Thailand
Noppadon Nuntawong National Electronics and Computer Technology Center (NECTEC), Thailand
Mati Horprathum National Electronics and Computer Technology Center (NECTEC), Thailand
Pitak Eiamchai National Electronics and Computer Technology Center (NECTEC), Thailand
Saksorn Limwichean National Electronics and Computer Technology Center (NECTEC), Thailand
Sitiruk Roytrakul National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand
Janthima Jaresitthikunchai National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand
Narumon Phaonakrop National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand
Champadeng Vongdala National Cancer Center, Lao PDR
Keooudone Thammavong National Cancer Center, Lao PDR
Toshimasa Umezawa National Institute of Information and Communications Technology (NICT), Japan
Atsushi Matsumoto National Institute of Information and Communications Technology (NICT), Japan
Kouichi Akahane National Institute of Information and Communications Technology (NICT), Japan